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An in vivo study reported that the relationship between intracellular copper and NLRP3 inflammasome activation, and copper depletion significantly inhibited classical NLRP3-mediated pyroptosis in SOD1-deficient mice [111]

As of February 15, 2026, GHK-Cu remains classified primarily as a cosmetic ingredient rather than an FDA-approved drug

Synonyms: Melanotan II

Biological aging involves: Collagen degradation Chronic low-grade inflammation (inflammaging) Reduced cellular repair Muscle decline Connective tissue degeneration Mitochondrial dysfunction Slower wound healing Oxidative stress accumulation GHK-Cu has attracted attention because studies suggest it may influence several of these pathways simultaneously