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Redox-active selenium compoundsfrom toxicity and cell death to cancer treatment

doi: 10.2527/jas.2008-1120 153 JinY.HuY.HanD.WangM

Certain drugs such as methotrexate and trimethoprim act as folate antagonists and can cause folate deficiency by inhibiting the enzyme dihydrofolate reductase, which converts unreduced dietary folates to the biologically active tetrahydrofolates [62]