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2.5 Mass Spectrometry Detection Detection of metabolites was performed using a Thermo Q Exactive Focusmass spectrometer (ThermoFisher Scientific, USA) with both positive and negative ESI models, respectively

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(64) further confirmed that a nanocurcumin formulation could overcome multidrug resistance in cancer cells and ameliorate doxorubicin-associated cardiomyopathy by reducing DOX-induced intracellular oxidative stress (an indicative of total glutathione levels and glutathione peroxidase activity) in cardiac tissue

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