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Accordingly, macrophage depletion via small molecule inhibition of the pro-survival receptor CSF1R is sufficient to reduce OL loss and demyelination in the cuprizone model, and administration of the ligand CSF1 is sufficient to cause demyelination 172

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They illustrated that 80 mg/d pyridoxine supplementation during 12 weeks reduced the headache diary results (HDR), severity, and duration of migraine attacks, compared with the placebo (59)