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Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

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The success of mitochondrial transplantation is likely dependent upon the source and quality of the isolated mitochondria, the delivery protocol, as well as the cellular uptake of supplemental mitochondria to ensure adequate neuronal uptake within the brain (Chang et al., Stem Cell Therapies in PD Addressing Mitochondrial Dysfunction Astrocytes derived from human iPSCs may be therapeutic in PD via the provision of a continuous supply of healthy mitochondria as a form of mitochondrial donation (Cheng et al., in vitro PD model to demonstrate that iPSCs-derived astrocytes or astrocytic condition media can rescue dopaminergic neurons through intercellular mitochondrial transfer (Cheng et al., Soluble Epoxide Hydrolase Inhibition There are multiple lines of evidence suggesting that soluble epoxide hydrolase (sEH) deficiency or inhibition can attenuate parkinsonism in MPTP-treated mice (Qin et al., 2015