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Thus, the outcome of EGT permeation across the BBB and accumulation in the brain points out a possibility that other transporters rather than OCTN1 may be responsible for EGT uptake and relocation, such as SLC22A15 (encoding fly-like putative transporter 1 or FLIPT1), albeit with a much lower affinity [74]

To view a copy of this licence, visit About this article Cite this article Almotawa, R.M

Chronic increases in ROS, pro-inflammatory cytokines and other damaging compounds released from immune cells and astrocytes have the ability to damage mature oligodendrocytes and OPCs, resulting in myelination impairments (Pang et al., 2003

Overall, these results demonstrate that a 62:38 ratio W/O disulfiram emulsion is stable and has excellent physicochemical properties for in vivo administration