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4.1.3 Tryptophan and its metabolites Tryptophan, an essential amino acid, exhibits intimate associations with gut microbiota functions through its metabolic pathways, particularly the synthesis of 5-HT that plays a pivotal role in regulating the ENS ( Lactococcus , Streptococcus , Escherichia coli , and Akkermansia muciniphila , activate TPH1 in ECCs through SCFAs, catalyzing the conversion of tryptophan to 5-HT (Reigstad et al., 2015)

Cysteine is oxidized to cystine which is readily transported into mammalian cells as a naturally occurring analog of cysteine 2

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