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McKenzie T, Liu Y, Fanale M, Swisher SG , Chada S, Hunt KK

Although heavy metal lacks a consistent definition in medical and scientific literature, the term is commonly used to describe the group of dense metals or their related compounds, usually associated with environmental pollution or toxicity

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One of the most well-studied experimental models of hypertension induction in rats, which was first developed by Selye (85) in 1943, involved the administration of deoxycorticosterone acetate (DOCA) and 1% NaCl for 7 weeks