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Additionally, we analyzed postmortem human brain tissue with histopathologically confirmed AD or progressive supranuclear palsy (PSP), an age-associated tauopathy that clinically manifests as parkinsonism with additional motor abnormalities and cognitive dysfunction, and is neuropathologically defined by NFTs, gliosis and neurodegeneration (104)

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During collagen synthesis in the endoplasmic reticulum, the prolyl-hydroxylase adds hydroxy to the proline in the collagen chain 40

Contaminants, even in trace amounts, can introduce confounding variables that invalidate your results