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While only a small fraction of -syn (~4%) is phosphorylated in healthy brains, substantial accumulation of pS129 (~90%) is observed in brains with Lewy pathology, implicating a potentially important association between this posttranslational modification and the accumulation of -syn aggregates concomitant with LB formation and neurodegeneration (Fujiwara et al., 2002

Persistently high levels of ROS lead to oxidative stress, cellular damage, dysfunction, and even cell death [181]

Therefore, the potential effects on offspring when metformin is used by pregnant females with PCOS should be thoroughly evaluated (Nguyen et al., 2018

The NF-B pathway regulates various factors upstream and downstream, further mediating the inflammatory response, oxidative stress response, liver fibrosis, cell apoptosis, autophagy and pyroptosis of liver tissue to promote the process of MASLD (384)