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Therefore, there is an urgent need to develop effective TXN inhibitors for clinical applications

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Enhancing the GSH/GSSG ratio via overexpression of GSR or GCLC lowers ROS levels and confers protection against H 2 O 2 - or TNF-induced apoptosis 35,36

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It can also increase the production of Reactive Oxygen Species (ROS), leading to elevated levels of oxidative stress

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