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doi: 10.1016/S0140-6736(18)31785-9 246 KaufmanAAbuqayyasLDenneyWSTillmanEJRolphT

On the other hand, anti-inflammatory factors such as IL-4, IL-10, IL-13, and TGF- lead to the neuroprotective M2a phenotype of microglia promoting the release of factors such as arginase-1, CD206 (macrophage mannose receptor), insulin-like growth factor 1 (IGF-1), Ym1 and FIZZ1, associated with neuroprotection and tissue repair (Glass et al., 2010