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Conversely, in another study, 615 patients with IGF-1 values in the lower half of the normal range were closely observed during 4.5 years

Some individuals may experience a modest reduction in weight, while others may not see significant changes

J Pharmacol Exp Ther 324:883893

10,11 In the IKEMA study, patients with multiple myeloma who had received one to three lines of previous therapy were randomized to the combination of isatuximab/carfilzomib/dexamethasone or carfilzomib/dexamethasone