does acetaminophen decrease glutathione

does acetaminophen decrease glutathione Frontiers GSH reduces NAPQI, the metabolite

Name: does acetaminophen decrease glutathione Frontiers GSH reduces NAPQI, the metabolite
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GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC Acetaminophen (Paracetamol) Toxicity Hepatotoxicity (Liver Injury) Adverse Effects Liver toxicity (acute hepatic injury) Elevated AST & ALT (may exceed 300010,000 IU L) Nausea, vomiting, diaphoresis (early) Right upper

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See also References Van Konynenburg, Rich (September 19, 2009)

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