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Several large meta-analyses found that alterations in KYN pathway metabolites were associated with mood, psychotic symptoms, and cognitive function in individuals with BD

Pathological hyperactivation of PI3K/AKT/mTOR signaling induces structural abnormalities including neuronal hypertrophy, axonal guidance defects, and disrupted connectivity patterns across brain regions (Heras-Sandoval et al., 2014)

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