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The association of muscle carnitine levels and acyl-CoA oxidation is the basis of a multi-million energy and weight loss nutraceutical industry

The combination of IHC, WB, and LCMS can achieve a complete ferroptosis chain of"phenotype-protein-lipid." Due to the complex process of ferroptosis and the lack of specific biomarkers, it is difficult for existing single detection methods to comprehensively capture its dynamic change characteristics

Notably, the identification of thalidomide and its analogs as CRBN ligands vastly expanded the E3 ligase toolbox [48], spurring a wave of VHL- and CRBN-based PROTACs such as ARV-825 and DBET1 that achieved potent degradation of BRD4 and AR in cellular models [49, 50]

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