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Iguchi Y, Eid L, Parent M, et al

J Dtsch Dermatol Ges 2015;13:768-75

Likewise, electrophysiology studies have found that caffeine ingestion up to 500 milligrams (mg)/day (equivalent to five to six cups of coffee per day) does not increase the frequency or severity of cardiac arrhythmia in healthy individuals or in those with coronary heart disease

The guide details experimental parameters for testing collagen production (1-100 M concentrations, 24-72 hour protocols), MMP activity measurement, and angiogenesis readouts