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4 Bidirectional crosstalk between neuroinflammation and ferroptosis in depression Although the individual roles of neuroinflammation and ferroptosis in the development of depression have received considerable attention, the bidirectional crosstalk between these processes and their specific molecular pathways remains relatively unexplored

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Transcriptional activity of the haptoglobin gene is promoted by interleukin-1, interleukin-6, and glucocorticoids as a part of the acute-phase response to systemic inflammation and related physiologic disturbances ( 116 , 117 , 118 , 119 , 120 ), thereby explaining why haptoglobin levels are increased with inflammation

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