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Common signs include: Sharp or throbbing joint pain Redness and swelling in the joint Warmth around the joint area Difficulty moving the affected joint Lingering discomfort even after the initial pain fades A gout flare-up can stick around for many days, even weeks

However, we did not detect any changes in the transcription of glt-1 after treatment with BSO (data not shown), suggesting that xct upregulation could lead to increased extracellular glutamate levels, as observed in mice that have been gestationally exposed to arsenic (Ramos-Chvez et al., 2015

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