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In another study with 118 CRC patient cases, HO-1 expression was significantly elevated in CRC tumor tissues when compared to paired normal non-tumoral and polyps samples

Schematic illustrating the process of xenobiotic metabolism, which encompasses three phases I, II, III (Adopted from [137]) as well as xenobiotic induced oxidative stress and molecular damage

The overlap between the genes downregulated by NAC and the SKN-1 (92 genes) or DAF-16 (189 genes) sets was statistically significant and over five-fold above chance (Fig

Despite extensive preclinical promise, antioxidant therapies have consistently failed in clinical translation