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Yes and because their mechanisms are complementary rather than redundant, combining them is one of the more compelling reasons to consider both

& Pavletich, N

The primary concern is off-target methylation interference

HUBERMAN: But in addition to that, that you really think about using the minimal effective dose and that you use perhaps even the mildest of these different compounds in order to make sure that you don't desensitize any of the receptor pathways