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We observed that addition of electron-withdrawing substituents on the phenyl ring increased the electrophilicity of the chloroacetamide carbon and improved potency of inhibition (Supplementary Table 1)

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Anti-nNOS (#ab76067) and anti-iNOS (#ab178945) antibodies were obtained from Abcam (San Jose, CA, USA), mouse anti--actin antibodies (#gb23301) were obtained from Servicebio (Wuhan, China), and rabbit anti-PDI antibodies (#bs-0295G-HRP) were obtained from Solarbio (Beijing, China)