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represents an important step in understanding the roles and functions of SLC25A39 as well as in the importance of GSH as a scavenging antioxidant

2442-C A3907, A CLINICAL SYSTEMIC APICAL BILE ACID TRANSPORTER INHIBITOR, REPROGRAMS FATTY ACID UTILIZATION TOWARDS OMEGA-6 METABOLISM PROMOTING REDUCED INFLAMMATION, FIBROSIS, AND STEATOSIS Kim Ekroos 1 , Fredrik Wngsell 2 , Martin Rnn Madsen 3 and Peter kerblad 2 , (1)Lipidomics Consulting Ltd., (2)Albireo AB, (3)Gubra Background: Nonalcoholic steatohepatitis (NASH) is characterized by build-up of fat within liver cells leading to fibrosis, steatosis, and hepatic injury

1417 Recent studies have also identified other enzymes involved in lipid peroxidation processessuch as acyl-CoA synthetase long-chain family member 4 (ACSL4) and lipoxygenases (LOXs)which participate in generating lipid peroxides associated with ferroptotic mechanisms

In recent years, osteoimmunomodulation is an important concept targeting the interaction between immune cells and osteogenesis-related cells, emphasizing the intrinsic link between the immune system and the bone regeneration sequence