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Description

S-containing metabolites, including amino acids methionine, major reductant glutathione, and specific metabolites, are synthesized from cysteine

63,64 Ultimately, through regulation at the tissue and organ levels, these processes influence the onset and progression of diseases in the organism

Glucoraphanin is the major glucosinolate associated with many health-benefits, as well as the prebiotic effects in broccoli

To identify which pathway contributes most to QEC tolerance to Cys-Cys limitation, we treated QECs with specific inhibitors targeting STAT3 and NRF2 activity: AG-490 [40] and ML385 [41], respectively