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Description

Typical protocols include enzyme-activity assays and metabolic-flux studies in cell and tissue models

Early intervention with TrkB partial agonist LM22A-4 increases parvalbumin-positive inhibitory synapses around cortical pyramidal neurons, upregulates Nav1.1 expression in interneurons, and reduces spontaneous seizures from 65 to 21%, demonstrating neurotrophic modulation of inhibitory synaptic plasticity (Gu et al., 2022