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130 , 988S990S (2000)

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Nat Med (2017) 23(1):1207

LCA inhibits Th1 differentiation in T cell lines, likely via Vitamin D Receptor (VDR) signaling, as siRNA knockdown of VDR attenuates this effect ( + T cell populations ( + T cell assays, suggesting a Th1-promoting role for select microbial BA metabolites that contrasts with LCAs inhibitory effects ( The microbiotaBA axis also intersects with T cell function via stress-response pathways, particularly in the BA-rich ileum