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In addition to the characteristic rash, features of classical lupus include: Profound fatigue that is unresponsive to rest Arthralgia in multiple joints and edema in multiple joints Spontaneous fever Photosensitivity in which sun exposure precipitates or aggravates the disease Alopecia or hair loss Mucous membrane lesions Raynaud's phenomenon, in which fingers and toes turn blue and white in cold temperatures Lupus complications arise when the disease infects organs of the body's middle segment

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In the following step, the extract was centrifuged at 5000 g for 10 min (4C)

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