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KU70 inhibition impairs both non-homologous end joining and homologous recombination DNA damage repair through SHP-1 induced dephosphorylation of SIRT1 in T-cell acute lymphoblastic leukemia (T-ALL) [corrected]

Jiang S-S, Xie Y-L, Xiao X-Y, Kang Z-R, Lin X-L, Zhang L, et al

6.3 Mechanistic understanding and complex interactions Although substantial progress has been found in recognizing the core pathways by which exercise may exert therapeutic effectsnamely through the regulation of oxidative stress and HPA axis functionour insight of the complicated relationship between these mechanisms continues to be incomplete

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