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The ASD-CFDS Connection: Epidemiological Evidence Multiple studies have detected a significantly higher prevalence of FR autoantibodies in children with Autism Spectrum Disorder (ASD) compared to neurotypical controls: Ramaekers et al

Example of toxic acetylated metabolite Liver damage Highly reactive specie Mechanism of acetylation Acetyl CoA is the activated carrier for acetyl group The reaction catalyzed by the soluble acetyltransferase enzyme: Mainly found in liver Might found in lung, spleen, GIT and red blood cells Acetylation The rate of acetylation is mainly affected by the existence of genetic polymorphism

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First characterized in 1977 from rabbit brain tissue extracts