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At the ultrastructural level, irregular and immature elastin fibers and fibers devoid of microfibrils were observed. These findings suggested that both elastic fiber abnormalities and reduced collagen content contribute to the clinical features seen in patients with clEDS. There were no consistent electron microscopy (EM) findings in the ten patients in our cohort who had EM performed

Histochemical and immunohistochemical study of mucinous rectal carcinoma

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Severe impairment: Confusion, disorientation, difficulty standing, nausea, increased risk of asphyxiation on vomit, and reduced pain sensitivity