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On the other hand, in HepG2 cells a totally reversed effect was noticed

In addition, the Molecular Signature Database 29 was used to investigate the hallmark gene sets

In order to further investigate the direct binding sites of EPS to KEAP1, we performed homology analysis on KEAP1 and predicted the possible binding sites of EPS to KEAP1 (SER363, ASN414, SER555, and SER602) (Fig S4B)