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Research has demonstrated that CD4 + T cell proliferation is apparent in both the peripheral blood of SLE patients and the renal tubulointerstitial compartment of individuals with proliferative lupus nephritis (PLN)

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Different chemical gradients being established throughout the biofilm community, in combination with limited diffusion and the metabolic activity of resident bacteria, leads to the emergence of distinct subpopulations that often cooperate metabolically but respond differently to the microenvironment depending on their location along the gradient (Penesyan et al., 2020)