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There is a gender-specific association between hypothyroidism and cholelithiasis, and males with gallstones should be screened for thyroid conditions

Inflammation: Excessive sugar and unhealthy fats promote the release of pro-inflammatory cytokines in the brain, leading to neuroinflammation, which is linked to impaired memory and learning as well as an increased risk of neurodegenerative diseases

Do normal liver enzymes prove that detoxification is normal

Moreover, structural and functional intestinal alterations arising from a lack of diversity in the microbiome have shown a correlation with increased heart failure related risk and incidence (Velasquez et al., 2016)