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Defining the correlation between immune-checkpoint inhibitors-related adverse events and clinical outcomes: a narrative review Omar Abdihamid 1 , Abeid Omar 2 and Tibera Rugambwa 3 1 Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, Peoples Republic of China 2 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Champlion Street, Alazarita, Alexandria 21131, Egypt 3 Department of Internal Medicine, Mbeya Zonal Referral Hospital, Mbeya 419, Tanzania Abstract Immune checkpoint inhibitors (ICIs) have increased modern anticancer armamentarium portfolios, with 15%60% of cancer patients deriving clinical benefit while others progress, including some occurrences of accelerated progressions

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The uniqueness of GHK is that it may allow simultaneous resetting of multiple genes to target an array of various biochemical pathways to increase resistance to cancer and reverse pathological epigenetic changes in cancerous cells