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While previous studies hint at possible kinase-regulated mechanisms for NHR-49, they lack residue-level specificity 16

Disruption of this inhibitory interaction allows increased nitric oxide production, which is relevant to endothelial signaling and vascular responsiveness in experimental systems [3]

In this study, we cultured organotypic whole brain slice cultures in the sagittal orientation to visualize the corpus callosum, allowing us to investigate demyelination and remyelination processes