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This is why people with stomach surgery, autoimmune gastritis, or long-term PPI use can develop B12 deficiency despite adequate dietary intake

Estimation of Cumulative AUC and Target Attainment For comparing the target attainment between cohorts, the individual cumulative AUC (cAUC) for each patient was derived from the integration of the concentration over time, using the empirical Bayes estimates of individual CL over the entire treatment course as follows: Target attainment was defined as the achieved cAUC divided by the target cAUC for the patient, multiplied by 100%

Through in-depth study of these mechanisms, future research has the potential to enhance our understanding of treatments for HAPH, identify new therapeutic targets, and establish a scientific foundation for clinical practice

Metabolic engineering of cofactor F420 production in Mycobacterium smegmatis