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10.2337/dbi22-0030 15 AssreuyA

In contrast, the same dose given intravenously, as used in the Pauling studies, would produce peak plasma concentrations of nearly 6 mM, more than 25 times higher

Among them, IL-1 and TNF- can enhance the expression of COX-2, PGE2 and MMPs in human RASFs (158, 188, 190), and play an important role in the development of RA