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Therefore, therapies targeting the Trx system in isolation may be insufficient or potentially imbalanced

Systematic review and meta-analysis have also implicated polyfluorinated substances [21], polychlorinated biphenyls [360], and plasticizers like phthalates [252] and bisphenol A [595]

A phase 3 double-blind, double-dummy, randomised controlled trial (RCT) comparing IPX203 with immediate-release (IR) LD/CD showed a statistically significantly greater increase in daily ON-time of + 0.53 h, and this difference was achieved with a mean of 3 daily doses vs 5 in the IR LD/CD arm [22]

J Lipid Res 40:10531063 Harats D, Shaish A, George J et al (2000) Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice