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NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the human body

PLoS ONE 8 , e57247 (2013)

152 Following the administration of NBDHEX, GSTP1 dissociated from both the GSTP1-JNK and GSTP1-TRAF2 complexes, indicating inhibition of GST activity

Not only would someone with a CBS up-regulation be losing methyl groups, as well as the primary antioxidant defense in every cell (glutathione), any additional methyl groups from diet or supplementation could cause a potential surge in CBS up-regulations