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Additional information Peer review information Nature Communications thanks Fabian Filipp and William Gallagher and the other anonymous reviewer(s) for their contribution to the peer review of this work

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Polekhina G, Board PG, Gali RR, Rossjohn J, Parker MW: Molecular basis of glutathione synthetase deficiency and a rare gene permutation event

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Methionine in the form of S-adenosylmethionine (SAM) is required for many methylation reactions, including DNA methylation

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