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Interestingly, with progressive increase in IOP, autophagy is initially activated in the dendrites of RGCs and protects cells, but its subsequent activation in the cytoplasm disrupts homeostasis and induces cell death 21,22,70,71,72

The cholinergic and glutamatergic receptor codes (Figs

Cells lacking NCOA4 exhibit reduced susceptibility to ferroptosis [98], indicating that the role of NCOA4 as a promoter of iron availability is indispensable in the execution of cellular death pathways

As ion channels are important therapeutic targets and many ion-channel drugs have already been approved for clinical trials, ORF3a is another good antiviral drug target 144