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2021;10:315 Rydz L, Wrbel M, Jurkowska H

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2 Ferroptosis 2.1 Mechanism of ferroptosis Ferroptosis, a recently discovered form of cell death, exhibits distinct morphological and biochemical characteristics ( Figure 1 )

(2012) demonstrated that specific mutations in Bacillus amyloliquefaciens PRS (BaPRS), specifically N120S and L135I mutations (BaPRS N120S , BaPRS L135I ), are conducive to the release the enzyme from ADP and GDP inhibition, remarkably increasing its sensitivity to activation of inorganic phosphate to promote synthesis of nucleosides compared with the wild-type BaPRS