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Despite the number and importance of such enzymes to cellular metabolism, few studies have been conducted to better understand the effects of MTX on cellular metabolic homeostasis or find metabolic fragilities that could be exploited clinically

It plays an important role in protecting cells from oxidative stress caused by pollution, UV exposure, and toxins

RES also inhibits LPS- and ATP-activated NLR family pyrin domain containing 3 (NLRP3) inflammasome and protects microglial cells from oxidative stress, proinflammatory cytokine production, and pyroptotic cell death resulting from inflammasome activation [79]

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