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100 Nuclear translocation of fructose-1,6-bisphosphatase 2 inhibits c-Myc-mediated gene expression, thereby suppressing mitochondrial biogenesis and respiration

Three replicate cultures were harvested (approximately 3 million cells each) by centrifugation at 6,000g for 10 minutes

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An understanding of the molecular mechanisms that determine selective vulnerability and resilience would shed light on the key processes that drive neurodegeneration and point to potential therapeutic strategies to protect vulnerable cell populations