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This epigenetic silencing can lock T cells into an exhausted state and impair memory T cell differentiation, weakening long-term immunity ( 3.2.1Succinate Accumulation and HIF-1 Stabilization Damage to the ETC, particularly at Complex II (succinate dehydrogenase), can lead to the accumulation of succinate

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& Fumagalli, M

While the exact PRR repertoire in epithelial cells is less extensively characterized compared to professional immune cells, emerging evidence indicates that CLRs (e.g., Dectin-1) and TLRs are involved in sensing C