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These findings initiated the study of the incretin hormone

Long-term inhibition of G6PDH activity and the associated impairment of the NADPH-generating system and glutathione (GSH)-replenishment system significantly increase the vulnerability of the affected cells to apoptosis

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However, a significant disadvantage is that they can only be used to deliver extremely small amounts of the drug (nanogramsmicrograms) because only a few centimeters of the suture is typically required for surgical repair