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JAK-inhibitors for the treatment of rheumatoid arthritis: A focus on the present and an outlook on the future

In addition, 2-hydroxyestrogens have been associated with normal cell differentiation and apoptosis [37]

Continued research in this domain can lead to personalized interventional and therapeutic approaches aimed at optimizing redox function, minimizing the risk of oxidative stress-mediated conditions, and ultimately promoting longevity

For example, -glucans from fungi can activate initiator caspase-8 and effector caspase-3, leading to mitochondrial cytochrome C release and apoptosis in cancer cells (132)