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2.4.3 Chitosan Chitosan is a natural polysaccharide derived from the deacetylation of chitin, commonly found in the shells of crustaceans such as shrimp and crab

HIF1alpha-dependent uncoupling of glycolysis suppresses tumor cell proliferation

[0339] The compound of Formula la at 100 mg/mL in water with 0.1% w/v HPMC, 0.5% w/v poloxamer 237, and 0.9% sodium chloride: The suspension vehicle containing the excipients HPMC, poloxamer 237, and sodium chloride was prepared as described above in Example 3

Notably, the optimal in vivo neuroprotective dose was identified as 0.5 mg/kg, which produced substantial behavioral and histological improvements