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In our society, these symptoms are considered normal signs of aging. In truth, they are signs of abnormal or accelerated aging processes

Hypoxia-inducible factor 1-alpha (HIF-1) may indirectly stabilize and activate the transcription of numerous genes involved in copper metabolism, including those controlling CTR1, thereby contributing to higher copper levels in tumor cells (62)

Specifically, treatment upregulates the molecular chaperone GRP78 to enhance protein-folding capacity and promote adaptation, while concurrently inhibiting the pro-apoptotic PERK/eIF2/CHOP axis and downstream activation of caspase-12 and caspase-3

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