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We first examined whether MIEAP, a molecule involved in noncanonical mitophagy, and ATG5, a component of autophagic machinery and involved in canonical mitophagy, are tumor suppressors in thyroid carcinogenesis using genetically engineered mice and found that thyroid cancer development was accelerated in Braf thyrV600E ,Atg5 thyrKO/KO and Braf thyrV600E ,Mieap KO/KO mice compared with Braf thyrV600E mice

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